the effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity

background : peroxisome proliferator-activated receptor gamma (ppar γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. it seems that long-chain polyunsaturated fatty acids (lc-pufas) can regulate ppar γ expression. the purpose of this study was to investigate the effects of n-3lc pufa supplementation on plasma levels of ppar γ and thyroid hormones in obesity. materials and methods : in a randomized double-blind controlled trial, 66 subjects with obesity were assigned to 2 groups. participants in intervention group consumed omega3 capsules contained 1000 mg n-3 fatty acids (180 mg of eicosapentaenoic acid [epa] and 120 mg of docosahexaenoic acid [dha]) and placebo group consumed placebo capsules contained paraffin twice a day for 4 wk. fasting blood samples and weight measurements were collected at the baseline and at the end of the trial. plasma ppar γ and thyroid hormones were measured by elisa. data were analyzed using a repeated measure model-two factor for comparing two groups in two times. result s: no significant changes were observed in ppar γ levels between and within the groups after supplementation ( p >0.05). n-3lc pufa supplementation significantly increased t4 levels after 4 wk ( p <0.05) but t3 and tsh did not change significantly. conclusion : our study showed that n - 3lc pufas supplementation increased t4 levels. however, no significant changes in t3, tsh and ppar γ plasma levels were observed in obese adults. key words : docosahexaenoic acid, eicosapentaenoic acid, n-3 lc pufas supplementation, obesity, peroxisome proliferator activated receptor gamma, thyrotropin, thyroxin, triiodothyronine normal 0 false false false en-us x-none ar-sa